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Loperamide

Indications: Diarrhea

Pharmacology: Slows intestinal motility, affects water and electrolyte movement through intestine, inhibits peristalsis, reduces daily fecal volume, increases viscosity and bulk density of stool, diminishes loss of fluid and electrolytes.

Contraindications: acute diarrhea associated with organisms that penetrate intestinal wall (eg, toxigenic Escherichia coli , Salmonella , Shigella ); Abdominal pain of unknown cause, especially if associated with fever

Dose: PO (Adults): 4 mg initially, then 2 mg after each loose stool. Maintenance dose usually 4–8 mg/day in divided doses (not to exceed 16 mg/day).

Pregnancy: Category B

ONSET: 1 hr, PEAK: 2.5–5 hr, DURATION: 10 hr

Education:
Inform patient that medication may cause dry mouth. Encourage patient to drink plenty of clear fluids to help prevent dehydration that may accompany diarrhea.
Advise patient to notify health care provider if diarrhea persists more than 48 h or if fever develops.
Inform patient that drug may cause drowsiness or dizziness and to use caution while driving or performing other tasks requiring mental alertness.

Sources:
A to Z Drug Facts (A2zDrugs™); DRUG GUIDE for Physicians (DrDrugs®)

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